Prima Mente

Prima Mente Decodes Brain Signals With AI Foundation Models

Prima Mente built the world's first whole-genome epigenetic foundation model Pleiades, driving breakthroughs in precision diagnostics and AI-first neuroscience research using the Nebius AI Cloud. The model achieved 0.89 accuracy for early-stage detection of Alzheimer's and Parkinson's using blood samples.

NVIDIA, Nebius & Prima Mente • February 2, 2026

Using Interpretability to Identify a Novel Class of Alzheimer's Biomarkers

We trained our epigenetics foundation model Pleiades to detect Alzheimer's from blood samples. Using interpretability methods, we identified DNA fragment length patterns as a novel class of biomarkers that generalize better than previously reported predictors.

Goodfire & Prima Mente • January 28, 2026

Towards a world free from neurodegenerative disease, starting with Pleiades

Our mission is to deeply understand the brain, protect it from disease, and enhance it in health. We introduce Pleiades, biological foundation models trained on the human epigenome, with applications for Alzheimer’s and Parkinson’s disease.

Prima Mente • July 16, 2025